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In vitro cytokine response to CpG DNA. Splenocytes were cultured in the presence of ODNs or DNA for 48 h (which was determined to be the optimal time for cytokine production). Supernatants were analyzed for secreted IL-6 (A) and IFN-γ (B) mRNA transcripts or secreted protein (C). In panel B, the arrow marks the IFN-γ band and the asterisk marks the internal GAPDH control band.
