TABLE 1.
Oligonucleotides containing immunoregulatory CpG motifs
HSV-derived ODNs were from the indicated HSV genes.
Stimulatory CpG motifs are boxed, and inhibitory CpG motifs (NCCGNN and NNCGRN) are singly underlined. The control ODN (nCpG) is similar to CpG except that the stimulatory motifs have been eliminated (a second control ODN in which the CpG motifs were reversed to GpC at both locations without other sequence changes resulted in responses similar to those of the nCpG ODN [data not shown]). The guanosine run in ICP27 is marked in bold. When 5′- and 3′-terminally modified PT oligonucleotides were used, the backbone linkages indicated in lowercase letters were substituted and the names have been hyphenated with PT (e.g., ICP27-PT). The sequences for the control nCpG and CpG oligonucleotides are from reference 46.