TABLE 4.
HSV DNA as adjuvant induces OVA-specific CD8+ CTL
| Adjuvant | No. of CTLs for stimulators pulsed with:
|
||
|---|---|---|---|
| Medium | gB (SSIEFARL) | OVA (SIINFEKL) | |
| CV-1 DNA | 1.0 ± 0.0a | 2.5 ± 0.5 | 17.5 ± 0.5 |
| HSV DNA | 8.5 ± 0.5 | 11.5 ± 2.5 | 78.5 ± 4.0 |
| nCpG-PT | 0.5 ± 0.7 | 2.0 ± 1.4 | 6.0 ± 1.8 |
| CpG-PT | 4.5 ± 2.1 | 6.5 ± 3.5 | 13.0 ± 8.1 |
| gD-PT | 5.5 ± 4.9 | 11.5 ± 4.9 | 56.0 ± 17.0 |
| ICP27-PT | 6.0 ± 2.8 | 7.0 ± 2.8 | 131.5 ± 13.4 |
| CFA | 20.5 ± 7.8 | 22.5 ± 12.0 | 69.5 ± 0.7 |
a
SFC in IFN-γ ELISPOTs using peptide-pulsed syngeneic splenocytes as stimulators. Medium column has unpulsed stimulators. Numbers are per 106 responder cells from duplicate wells.