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. 2003 Oct;77(20):11027–11039. doi: 10.1128/JVI.77.20.11027-11039.2003

FIG. 10.

FIG. 10.

ER targeting partially restores the NFAT activation mediated by mutant p12I 15-47. (A) Localization of mutant 15-47 and chimeric protein 15-47KKLL. An ER targeting signal, KKLL, redirected the chimeric protein 15-47KKLL to ER compartments stained with the ER marker, calreticulin (CRT). The nuclei were stained with Hoechst stain. (B) Relative NFAT activities mediated by p12I, mutant 15-47, and chimeric protein 15-47KKLL. Data are presented as relative NFAT luciferase activities compared to wild-type p12I. Values are means of three independent transfection experiments. Statistical significance was analyzed by using the Student t test. ✽, P < 0.05.