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Hydrogen bond network implicating His103. The backbones of monomers A and B are, respectively, shown in green and yellow. In the closed conformation, Tyr32 interacts directly with the side chain of His103, whereas His120 contacts the side chain of Gln342 in the interaction with Tyr32. In the open conformation, the two histidines are implicated in a water-mediated H-bond network with Tyr32.
