Table 2.

Polymorphisms in 10 loci of P. falciparum

Gene	Chr	Length, bp	ni	Dn	Ds	Synonymous sites per locus		Total synonymous sites analzyed
						4-fold (li)	2-fold (mi)	4-fold (nili)	2-fold (nimi)
Dhfr	4	609	32	4	0	67	129	2,144	4,128
Ts	4	1,215	10	0	0	125	264	1,250	2,640
Dhps	8	1,269	12	5	0	128	227	1,536	2,724
Mdr1	5	4,758	3	1	0	450	696	1,350	2,088
Rap1*	—	2,349	9	8	0	289	461	1,092	1,668
Calm	14	441	7	0	0	52	86	364	602
G6pd	14	2,205	3	9‡	0	242	468	726	1,404
Hsp86	7	2,241	2	0	0	266	455	532	910
Tpi	—	597	2	0	0	90	131	180	262
Csp1 5′end†	3	387	25	7	0	30	90	688	2,010
Csp1 3′end	3	378	25	17	0	42	65	1,050	1,625
Total		16,449	130	51	0	1,781	3,072	10,912	20,061

Chr is the chromosome on which the locus is located, when known; n_i is the number of sequences; D_n and D_s are the observed number of nonsynonymous and synonymous polymorphisms, respectively; l_i and m_i are the numbers of 4-fold and 2-fold synonymous sites examined. 

^*Rap1 sequences are not complete in all nine isolates examined; values of m_i and l_i are based on the complete gene sequence. 

^†Two short indels occur among the 5′ sequences of Csp1; m_i and l_i are given for the longest sequences (M15505 and M87173). We have excluded the central repeat region of the Csp1 gene, which codes for a variable number of repeats of motifs 4 amino acid long. 

^‡In addition to the nine nonsynonymous polymorphisms, there is a 3-bp indel at nucleotides 1,066–1,068.