Figure 1.

Simulations of rearranging a duplicated yeast genome and then reconstructing its original structure. The number of steps taken by our program to bring about symmetry in a configuration of blocks is plotted against the number of reciprocal translocations in the simulation that brought about the original block configuration. Each point represents the shortest of 10 simulations of a 5,790-gene genome with 446 pairs of retained paralogs. Five runs were carried out for each value on the x-axis. Circles indicate the average fraction of the genome that could be assigned to duplicated blocks in simulations (using a minimum of three duplicated genes per block); this fraction declines as more reciprocal translocations are made.