Figure 2.
Severe atelectasis of the lung and reduced expression of SP-D in CREB null mice. Histological analysis of lungs from a CREB −/− animal (B) and a control wild-type littermate (A), stained with hematoxylin/eosin and showing a severe atelectasis of the lung in CREB mutant animals. (C) Northern blot analyses of total lung RNA (5 μg) using probes specific for SP-A, SP-B, SP-C, and SP-D. Filters were rehybridized with β-actin as a loading control.