Table 1.
Subpopulations in thymus and spleen of C57BL/6, C2D, wild-type reconstituted, and EA137/VA142 Aβ mutant tg mice
| C57BL/6 | C2D | WT tg | EA137/ VA142 tg | |
|---|---|---|---|---|
| Thymus | ||||
| CD4 SP | 12.7 (2.6) | 2.0 (0.8) | 12.6 (2.8) | 5.7 (1.9) |
| CD8 SP | 4.0 (1.6) | 5.9 (1.8) | 4.3 (1.6) | 8.1 (2.2) |
| Spleen | ||||
| CD3+CD4+ | 24.1 (7.2) | 2.4 (0.6) | 24.4 (8.1) | 8.8 (2.8) |
| CD3+CD8+ | 11.8 (2.0) | 18.5 (3.4) | 15.9 (3.4) | 17.9 (4.6) |
Mean percent (of total lymphocytes) and SD (in parentheses) of indicated subpopulations in thymus and spleen of C57Bl/6 (n = 8). C2D (n = 10), wild-type (WT) reconstituted (n = 22), and EA137/VA142 Aβ mutant (n = 22) tg animals. Comparing wild-type reconstituted and EA137/VA142 Aβ mutant transgenics, the differences in the number of CD4 SP cells in the thymus and spleen are significant, P < 0.05 and P < 0.005, respectively (Student’s t test). No other differences are significant.