Table 2.

TCR Vβ8-specific CD8⁺ T cells isolated from TCV mice kill human B cells cotransfected with murine Qa-1^b and Vβ8 cDNAs

Target	Expression		Cytotoxicity, %
	of
	Qa-1b	Vβ	CTL line 48 (3 exps.)	CTL line 49 (2 exps.)	CTL line 51 (5 exps.)
C1R	−	−	<1	<1	<1
C1R/Vβ8.2-6d	−	8	<1	<1	<1
J1	+	−	<1	<1	<1
J1/Vβ6-S3	+	6	<1	<1	<1
J1/Vβ6-S7	+	6	<1	<1	<1
J1/Vβ8.2-b	+	8	36.7  ± 2.8	49.5  ± 6.7	25.4  ± 3.8
J1/Vβ8.2-2e	+	8	30.9  ± 3.5	38.3  ± 1.9	30.3  ± 7.4
J1/Vβ8.2-9f	+	8	43.2  ± 6.5	49.9  ± 13.5	21.7  ± 5.0

TCR Vβ8-specific effector cells were prepared from activated CD4⁺Vβ8⁺ T cell-vaccinated AKR mice as described in Table 1. The FACS CTL assay was used for detecting TCR Vβ specificity of the CD8⁺ T cells as described (13). Cytotoxicity data are mean ± SD for the indicated number of experiments.