Figure 5.

Selectivity of MTX impairment of growth by transformed and nontransformed cells in media of different composition. Assays (3°) were prepared with 10³ SA′ cells mixed with 10⁵ standard passage A′ or 10⁵ A′ cells alone in either MCDB 402 or DMEM, both with 2% CS. They were treated with the indicated concentrations of MTX from days 3 through 6, then incubated without MTX to 14 days when they were trypsinized and counted. SA′ + A′ cells in MCDB 402, □ or in DMEM, ▪; A′ cells in MCDB 402, ▵ or in DMEM, ▴.