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Schematic representation of positions 138 and 167 within a glutamate dehydrogenase trimer looking along the trimer-trimer axis (same line-of-sight as Fig. 1 ▶). (a) D167T: all six residues are occupied by uncharged Thr. (b) Wild type: Asp at positions 167 are negatively charged. (c) T138E: Asp at positions 167 and Glu at positions 138 are negatively charged. The distance between any two closest neighbors is about 10 Å.
