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. 1998 Apr 14;95(8):4579–4583. doi: 10.1073/pnas.95.8.4579

Figure 4.

Figure 4

Prevention of MDA-MB-435 (A) and MCF-7 (B) tumor formation by mAb 26–2F or cAb 26–2F. Tumor cells [5 × 105 (A) or 1 × 106 (B) per mouse] were injected into the surgically exposed mammary fat pad on day 0. For MCF-7 cells, a 17β-estradiol pellet was implanted in each mouse as a source of exogenous estrogen. Within 30 min of tumor cell injection the mice were treated with local subcutaneous injections of either PBS (♦) or Igs [mAb 26–2F (▪), cAb 26–2F (□), MOPC 31C (⋄); 240 μg/dose (A) and (B)]. Mice were then treated locally with 120 μg/dose (A) or 240 μg/dose (B) 6 times per week until sacrifice on day 28. n = 10 for all groups.