Table 2.
Combined pair/surf energy score and % identities for sequence-structure alignments of the PYRIN domain sequences to the death domain-fold family structures
| PYRIN | NBS1 | CARD7 | zCASP13 | ASC | AIM2 | IFI16 | MNDA | |
| Pair/surf score | ||||||||
| 1a1z | 5.12 | 5.37 | 4.86 | 7.62 | 6.21 | 4.95 | 5.20 | 6.91 |
| 1dgn | 0.51 | 3.41 | 4.02 | 5.52 | 4.43 | 3.71 | 4.39 | 5.95 |
| 1cy5 | 5.10 | 4.34 | 5.45 | 6.82 | 6.22 | 5.36 | 3.61 | 5.40 |
| 3ygs.P | 5.87 | 5.72 | 5.29 | 6.38 | 5.87 | 6.29 | 5.45 | 5.11 |
| 3crd | 4.16 | 4.14 | 4.36 | 3.33 | 4.00 | 3.46 | 4.11 | 3.73 |
| 1ddf | 5.68 | 5.13 | 4.92 | 6.21 | 4.36 | 5.50 | 5.49 | 3.92 |
| 1ngr | 4.68 | 4.45 | 5.57 | 6.54 | 5.74 | 4.86 | 3.34 | 6.46 |
| 1d2z.A | 6.53 | 4.14 | 5.28 | 6.91 | 3.94 | 4.02 | 3.76 | 5.58 |
| 1d2z.B | 6.00 | 4.95 | 5.21 | 3.13 | 3.57 | 1.83 | 4.89 | 4.51 |
| 1fad | 4.99 | 5.22 | 5.24 | 6.99 | 5.80 | 4.98 | 5.28 | 5.59 |
| % Identity | ||||||||
| 1a1z | 13 | 21 | 18 | 15 | 22 | 13 | 12 | 18 |
| 1dgn | 17 | 13 | 15 | 12 | 19 | 12 | 21 | 17 |
| 1cy5 | 13 | 13 | 18 | 15 | 16 | 13 | 21 | 24 |
| 3ygs.P | 16 | 11 | 18 | 11 | 21 | 14 | 18 | 15 |
| 3crd | 11 | 9 | 15 | 13 | 13 | 9 | 14 | 15 |
| 1ddf | 13 | 8 | 15 | 10 | 11 | 16 | 19 | 19 |
| 1ngr | 16 | 14 | 22 | 16 | 10 | 15 | 20 | 18 |
| 1d2z.A | 20 | 13 | 10 | 9 | 13 | 10 | 18 | 16 |
| 1d2z.B | 14 | 14 | 10 | 12 | 12 | 10 | 21 | 14 |
| 1fad | 20 | 10 | 12 | 17 | 13 | 9 | 15 | 20 |
The pair/surf scores and % identities listed were obtained using default parameters. The PDB codes correspond to the following death domain-fold family members: 1a1z, FADD DED (Eberstadt et al. 1998); 1dgn, ICEBERG CARD (Humke et al. 2000); 1cy5, Apaf-1 CARD (Vaughn et al. 1999); 3ygs.P, caspase-9 CARD (Qin et al. 1999); 3crd, RAIDD CARD (Chou et al. 1998); 1ddf, Fas DD (Huang et al. 1996); 1ngr, p75 neurotrophin receptor DD (Liepinsh et al. 1997); 1d2z.A, Pelle DD (Xiao et al. 1999); 1d2z.B, Tube DD (Xiao et al. 1999); 1fad, mFADD DD (Jeong et al. 1999).