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Comparison of MurF with the closed-form of MurD. (A) An overlap of the structures of MurD (gray) and MurF (colored by domains as in Fig. 3 ▶) is shown based on alignment of the central domains. (B) Structural alignment of the C-terminal domains of MurD (gray) and MurF (red). (C,D) The locations of invariant residues conserved among MurC, MurD, MurE, and MurF enzymes are highlighted in magenta on the structures of MurF with compound 1 (C) and MurD with substrate (D).
