Table 1.

Asymmetrical clusters in the U₁₀

Cluster	PMF difference (kcal/mol)	Gly/Pro preference	%	Remarks
Um	0.95	Gly 6	0.19	C-capping helix
Un	0.46	Gly 6	0.13	C-capping helix
Uo	0.23	Gly 5, 6; Pro 6	0.05	helix + loop + helix
Up	0.41	Pro 3, 5	0.11	N-capping helix
Uq	0.39	Pro 5	0.04	strand + 310-helix

Column 1 is the name of the cluster described in the text. Column 2 is PMF difference, which indicates the difference in PMF value between the center (v₁,v₂,v₃) of each cluster and that at the opposite position (v₁, −v₂,v₃) on v₂. Column 3 is the position where Gly or Pro has a preference of 1.0 or more. Column 4 is P_all for each cluster. Structures picked from the asymmetrical clusters in U₁₀ are shown in Figure 1A ▶.