Table 2.

Sequence families and structures investigated in this work

Protein family	COG #	# Seqa	PSZb	# PMsc	Structure(s) investigated
Dihydroorotase	0044	69	−1.8	7	1j79
Enolase	0148	73	−1.8	12	(see Table 3)
Triosephosphate isomerase	0149	69	−1.5	8	(see Table 1)
Transaldolase	0176	64	−1.5	7	1onr
Fructose-bisP aldolase	0191	71	−2.0	6	1dos
Deoxyribose-P aldolase	0274	44	−2.0	6	1rvg
Thiamine-P synthetase	0352	60	−1.5	3	2tps
Methylenetetrahydrofolate reductase	0685	51	−2.0	6	1b5t

^a Number of sequences in the alignment.

^b Phylogenetic similarity z-score threshold used in identification of the phylogenetic motifs.

^c Number of phylogenetic motifs identified.