Figure 5.

Current level of structural annotation of sequence databases. Progression (left to right) showing how the number of links to known structure in Swissprot increases as more sensitive methods are used. PDB shows those proteins of known structure; HSSP augments these with their close homologs; “SMART + Pfam” are links added by matches to domains themselves linked to structures; “PB or Andom” increases this further via PSI-BLAST or Andom assignments; “Unique” are those assigned by our seven new domains found with merged profiles (Table 2).