Table 3.

More detailed analyses of the seven novel predictions

Family	E-value	Predicted fold	3D PSSM	FUGUE	SUPERFAMILY	Sec Str (JPRED)
DagKaa	0.003	4 helical cytokine	—	TAF(II)230 TBP-binding fragmentb	—	All α
Glyco_hydro_39	0.085	TIM β/α barrel	TIM β/α barrel	TIM β/α barrel	TIM β/α barrel	α/β
K1	0.21	Ig-like β-sandwich	Ig-like β-sandwichb	Ig-like β-sandwich	Ig-like β-sandwich	All β
Ndr	0.023	α/β hydrolase	α/β hydrolase	α/β hydrolaseb	α/β hydrolase	α/β
Phosphodiesta	0.001	Alkaline phosphatase- like	Alkaline phosphatase- like	Alkaline phosphatase- like	Alkaline phosphatase- like	α/β
Transposase 12	0.17	λ-repressor like DNA binding	Sigma 70 from RNA polb	Methyltransferaseb	—	All α
Sigma54_factors	0.0011	λ-repressor like DNA binding	Sigma 70 from RNA polb	β graspb	—	All α

^a Families identified by PSI BLAST profiles, others are identified by HMM profiles.

^b Hits with scores above significance threshold (as described in methodology).