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Energy predicted using the sum of the FDPB side-chain desolvation energy, FDPB side-chain/backbone screened Coulombic energy, FDPB side-chain/side-chain screened Coulombic energy, and ORBIT van der Waals energy vs. the experimentally determined stability of each ho-meodomain variant. The energies obtained using the two-body FDPB approximation are shown as filled circles, and the energies obtained using the exact FDPB model are shown as open circles.
