Figure 2.

(A) APDs of five-residue stretches belonging to intrinsically disordered proteins (IDPs) or regular secondary structure elements within folded proteins and IDPs. (B) Deviation between the APD of entire proteomes and the APD of segments belonging to regular secondary structure or IDPs as a function of the organism complexity. The organism complexity is measured by the APD deviation from P. tetraurelia, d_xP. Solid lines are drawn solely to guide the eye. (C) From lower to higher eukaryotes, the decrease of β-aggregation propensity is related to the increase of intrinsically disordered proteins.