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Reagent interaction effects on Cdc25A refolding and crystallization. (A) The interaction between NDSB 201 and BMC on Cdc25A refolding identified from the primary screen was tested by varying NDSB 201 (0–1 M) and BMC (0–5 mM) concentrations to identify the optimal reagent combination. Activity was measured as described and a 36-fold increase over baseline lacking both reagents was observed. (B) Cdc25A crystals. (C) Ribbon diagram for the 2.2 Å crystal structure of refolded Cdc25A.
