Figure 5.
Putative calcium binding sites. Sequence homology with laminin α2 LG5 domain indicates the potential for similarity in calcium binding function, utilizing amino acid residues D163 and Q89. The amino acid side chain of E85 is in close proximity is also indicated. A second potential Ca2+ binding site is indicated near amino acid residues D125 and D145. (A) Ribbon diagram. (B) Electrostatic surface, identical orientation as that shown in panel A. (C) 60° rotation of model with respect to panel B to show Ca2+ binding site D163Q89. (D) 120° rotation of model with respect to panel B to show Ca2+ binding site D125D145.