Figure 7.

Putative heparin binding site. (A) Interactions between heparin and Npp α1(XI) collagen were predicted. For each heparin ligand, one job of 100 docking runs was performed using a population of 200 individuals and an energy evaluation number of 2 × 10⁶ employing the Lamarckian Genetic Algorithm. A further refined docking was centered at the putative heparin binding site on residues 147–152 (KKKITK). (B) Amino acids 147–152 form a track of positively charged side chains on the surface of the protein.