Table 2.
Ka(Xe)a/M−1 | Cavity volumeb/Å 3 | |||
H1-β3 cavity | β4-H4 cavity | H1-β3 cavity | β4-H4 cavity | |
Inactive | 27 ± 8 | 35 ± 8 | 74c | 92c |
Active | 27 ± 8 | 22 ± 8 | 58d | 116e |
a Xenon binding affinities were determined as described in the Materials and Methods section.
b Cavity volumes were calculated from:
d this work,
e this work with Tyr106 rotated to the out position.