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Cartoon plots of the crystal structures of human IgG1 Fab (PDB code 1UCB) (A) and Fc (PDB code 1H3X) (B). The two chains are in cyan and yellow and the carbohydrate moieties are in gray. Modified lysine residues in huN901–DM1 are mapped to the corresponding residues in huIgG1 and are shown in red. In the Fc fragment, the modified lysine residues are only labeled in one chain. The N and C termini are labeled as N-and C-, respectively. The protein images were created using Rasmol V2.6.
