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OGF has no effect on CKI p27 expression. BxPC-3 cells were synchronized by nocodazole (67 ng/ml) for 24 hours, and subsequently treated with 10-6 M OGF for 3, 6, 9, 12, 15, 18, or 21 hours. (A) Total protein lysates were resolved by SDS-PAGE and subjected to antibodies specific to p27. (B) Densitometic analysis revealed changes in p27 expression of less than 38% between OGF and sterile water treated values; none of these changes were statistically significant.
