Table 1.
Schedule of study activities
| Unpaired Group Injections | Paired Group Injections | |||||
|---|---|---|---|---|---|---|
| Study Phase | No.of Days | 11:00 | 19:00 | 11:00 | 19:00 | Stimulus Presented |
| Acclimation | 6 | - | - | - | - | - |
| Acclimation Injections | 8 | Saline | Saline | Saline | Saline | - |
|
| ||||||
| Nicotine Phase 1 | 14 | Nicotine | Saline | Saline | Nicotine | 19:05-19:25 |
| Test 1: Circadian Effects | 3 | - | - | - | - | - |
|
| ||||||
| Nicotine Phase 2 | 7 | Nicotine | Saline | Saline | Nicotine | 19:05-19:25 |
| Test 2: Stimulus Effects | ||||||
| Normal Time | 2 | - | - | - | - | 19:05-19:25 |
| Novel Time | 2 | - | - | - | - | 11:05-11:25 |
|
| ||||||
| Nicotine Phase 3 | 7 | Nicotine | Saline | Saline | Nicotine | 19:05-19:25 |
| Test 3: Probe Test | ||||||
| Novel Time | 1 | Saline | Nicotine | Nicotine | Saline | - |
| Circadian Effects | 1 | - | - | - | - | - |
| Normal Time | 1 | Nicotine | Saline | Saline | Nicotine | - |
| Circadian Effects | 1 | - | - | - | - | - |
|
| ||||||
| Final Baseline | 4 | - | - | - | - | - |