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. Author manuscript; available in PMC: 2009 Jan 15.
Published in final edited form as: Dev Cell. 2008 Jan;14(1):62–75. doi: 10.1016/j.devcel.2007.10.017

Figure 6.

Figure 6

Microarray analysis of E10.5 embryos. (A) Heat maps of probe sets in Affymetrix microarrays that showed at least a 3-fold induction (left and middle) or a 3-fold reduction (right) of expression in E2f7-/-E2f8-/- relative to wild type embryos. Data are presented as the medium of 4 embryos from wild type, E2f7-/-E2f8+/+ and E2f7+/+E2f8-/- genotype groups, and the medium of 2 embryos from E2f7+/-E2f8+/- and E2f7-/-E2f8-/- genotype groups. Red and green indicate induction and reduction respectively. Probe sets representing genes of interest are indicated. (B) The expression of 8 target genes (6 up-regulated and 2 down-regulated) was evaluated by real-time RT-PCR assays. (C) Pie chart diagrams illustrate the non-random distribution of the stress-related genes among the total 88 up-regulated genes in DKO embryos.