Table 1.

Parameters of lung inflammation in TLR2 KO and WT mice 24 and 48 h after infection with WT S. pneumoniae D39.

	24 h		48 h
	WT	TLR2 KO	WT	TLR2 KO
TNF-α	1229 ± 351	1026 ± 212	500 ± 92	361 ± 63
IL-1β	4029 ± 599	3248 ± 495	2874 ± 594	1462 ± 329*
IL-10	62 ± 23	48 ± 14	123 ± 51	72 ± 13
MIP-2	5912 ± 876	5689 ± 1039	1447 ± 177	1182 ± 243
KC	5943 ± 867	2244 ± 510**	3481 ± 339	695 ± 90**
MPO	7668 ± 1123	6158 ± 2317	9183 ± 2365	4057 ± 578***
TLIS	16.7 ± 0.9	16.8 ± 1.0	13.5 ± 0.6	15.5 ± 0.8

Mice were intranasally infected with 5 × 10⁷ cfu WT S. pneumoniae D39; whole lung homogenates were obtained 24 and 48 h thereafter. Data are means ± SEM (n = 6–8 per group).

^*P < 0.05 versus WT mice.

^**P < 0.005 versus WT mice.

^***P < 0.01 versus WT mice.

TNF-α, IL-1β, IL-10, MIP-2 and KC values are in pg ml⁻¹; MPO values are in ng ml⁻¹; TLIS (total lung inflammation score) in arbitrary units.