Table 2.

Parameters of lung inflammation in TLR2 KO and WT mice 24, 48 and 72 h after infection with pneumolysin-deficient S. pneumoniae PLN.

	24 h		48 h		72 h
	WT	TLR2 KO	WT	TLR2 KO	WT	TLR2 KO
TNF-α	325 ± 77	295 ± 87	195 ± 34	195 ± 34	506 ± 114	522 ± 163
IL-1β	2414 ± 519	903 ± 496*	552 ± 215	802 ± 200	1724 ± 638	2092 ± 956
IL-10	BD	BD	BD	BD	135 ± 27	153 ± 63
MIP-2	2703 ± 1033	1956 ± 1001	1919 ± 194	2720 ± 649	1029 ± 589	1297 ± 692
KC	1781 ± 791	600 ± 158	1700 ± 980	610 ± 188	1385 ± 323	958 ± 391
MPO	3173 ± 391	1666 ± 411*	1675 ± 424	2205 ± 226	2722 ± 251	2402 ± 500
TLIS	7.7 ± 2.0	3.1 ± 1.2	6.9 ± 1.6	11.9 ± 2.1	5.6 ± 0.9	8.7 ± 0.8*

Mice were intranasally infected with 5 × 10⁷ cfu S. pneumoniae PLN; whole lung homogenates were obtained 24, 48 and 72 h thereafter. Data are means ± SEM (n = 6–8 per group).

^*P < 0.05 versus WT mice.

TNF-α, IL-1β, IL-10, MIP-2 and KC values are in pg ml⁻¹; MPO values are in ng ml⁻¹; TLIS (total lung inflammation score) in arbitrary units.

BD, below detection limit.