Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Traditional and computational approaches to selection of the Maximum Recommended Starting Dose (MRSD) for Phase 1 clinical trials.
Figure was reprinted from Regulatory Toxicology and Pharmacology 40: 185–206 (2004), “Estimating the safe and staring dose in phase I clinical trials and no observed effect level based on QSAR modeling of the human maximum recommended daily dose”, by J.F. Contrera, E.J. Matthews, N.L. Kruhlak, and R. D. Benz [79], with permission from Elsevier.
