Figure 1.

In vivo expression of TNFα inhibitor after injection into rabbit knees with a.i.a. Twenty-four hours after induction of a.i.a. two groups of eight rabbits were injected in the left knee with either 7 × 10⁷ pfu of Ad.sTNF-RI-Ig or 7 × 10⁷ pfu of Ad.sTNF-RI-Ig and Ad.sIL-1-RI-Ig. Both groups were injected with 7 × 10⁷ pfu of Ad.lacZ in the right knee. At days 3 and 7 after injection of virus the knees were lavaged and the recovered fluids were analyzed by ELISA for levels of human type I TNFα soluble receptor (sTNF-R).