Table 3.

Primary Associations in BRIGHT Subjects, p < 1 × 10⁻⁵

Trait	Chr	Position	SNP	Genes	MAF	A1	A2	Additive	Effect	95% CI	p	R2
Serum Biochemistry
Albumin	3	125256768	rs9289231	KALRN	0.09	T	G	+	−0.77	−1.09, −0.45	2.91 × 10−6	1.20
Calcium	3	8114779	rs527498	-	0.36	G	A	+	−0.02	−0.03, −0.01	6.45 × 10−6	1.34
Chloride	5	52417975	rs12521915	ITGA2	0.37	C	G	+	0.54	0.30, 0.78	8.09 × 10−6	1.41
Cholesterol	11	116175886	rs6589567	ApoA5	0.11	C	A	+	0.28	0.17, 0.39	7.76 × 10−7	1.48
Cholesterol	1	109526922	rs4970834	CELSR2	0.20	C	T	+	−0.21	−0.30, −0.12	1.70 × 10−6	1.42
Cholesterol	16	81115185	rs10514542	-	0.28	G	C	+	0.18	0.10, 0.25	6.98 × 10−6	1.23
Cholesterol	14	54967291	rs4470077	TBPL2	0.19	A	G	+	0.20	0.11, 0.28	9.04 × 10−6	1.20
GGTa	9	114895784	rs17819305	TNC	0.09	C	T	×	1.20	1.12, 1.29	1.74 × 10−7	1.50
GGT	2	44238574	rs2333825	-	0.43	G	A	×	1.10	1.06, 1.15	2.68 × 10−6	1.21
GGT	22	16857154	rs10854521	-	0.24	G	A	×	0.90	0.86, 0.94	7.44 × 10−6	1.11
Glucose	22	43065788	rs739161	-	0.30	T	C	×	0.97	0.95, 0.98	3.75 × 10−6	1.68
HDL	10	132089471	rs11017236	-	0.16	T	A	×	1.06	1.04, 1.09	5.67 × 10−7	1.51
HDL	11	102903507	rs11826048	-	0.09	C	T	×	0.92	0.90, 0.95	9.70 × 10−7	1.45
HDL	3	15540326	rs905648	COLQ	0.34	C	T	×	0.96	0.94, 0.98	4.58 × 10−6	1.28
LDLa	1	109534208	rs599839	PSRC1, CELSR2	0.24	A	G	×	0.95	0.93, 0.97	1.05 × 10−7	1.71
LDL	2	51183769	rs11889082	-	0.08	A	G	×	1.08	1.05, 1.12	1.22 × 10−6	1.44
LDL	8	129112227	rs6470600	NA	0.03	G	A	×	0.89	0.85, 0.94	8.68 × 10−6	1.21
Triglyceridea	11	116157633	rs6589566	APOA5	0.06	A	G	×	1.28	1.19, 1.37	2.89 × 10−11	2.65
Triglyceridea	8	19876926	rs17482753	LPL	0.11	G	T	×	0.84	0.79, 0.89	1.17 × 10−9	2.22
Triglyceridea	2	27652888	rs780094	GCKR	0.39	C	T	×	1.10	1.06, 1.14	4.99 × 10−7	1.54
Triglyceride	19	36032592	rs17545624	-	0.29	A	G	×	1.10	1.06, 1.14	2.13 × 10−6	1.36
Uratea	4	9642649	rs7442295	SLC2A9	0.21	A	G	+	−0.02	−0.03, −0.02	1.85 × 10−15	3.48
Urate	8	42088927	rs7840827	-	0.20	G	A	+	0.02	0.01, 0.02	1.84 × 10−6	1.28
Urea	12	38609908	rs11174338	SLC2A13	0.12	G	T	×	1.06	1.03, 1.08	7.91 × 10−6	1.10
Urine Biochemistry
Albumina	12	102813190	rs11111839	XR_015316.1	0.06	C	A	×	1.61	1.35, 1.93	2.51 × 10−7	2.31
Albumina	3	19758281	rs17006217	-	0.13	T	C	×	0.72	0.64, 0.82	4.52 × 10−7	2.21
Creatinine	11	21910263	rs324175	-	0.09	C	T	×	0.87	0.82, 0.92	6.03 × 10−7	1.97
Potassium	22	17950507	rs737857	-	0.10	A	G	×	1.12	1.07, 1.18	2.19 × 10−6	1.76
Potassium by volume	23	122355911	rs4474149	-	0.38	G	A	+	−3.86	−5.54, −2.19	5.88 × 10−6	1.62
Potassium by volume	10	91689651	rs1419112	-	0.06	C	T	+	−9.34	−13.31, −5.38	4.02 × 10−6	1.69
Sodiuma	20	1936599	rs6035310	PDYN	0.18	A	C	×	1.13	1.08, 1.18	2.32 × 10−7	2.10
Sodium	2	133366441	rs10496693	Q6ZVE2_HUMAN	0.25	G	A	×	1.09	1.05, 1.14	3.24 × 10−6	1.71
Creatinine clearance	1	58615359	rs706430	-	0.42	G	A	+	−4.49	−6.45, −2.52	8.02 × 10−6	1.66

Only the SNP with the lowest p value for each region is shown. Genes listed are within 20 kb of the associated SNP or within the LD block estimated from HapMap data. MAF stands for minor allele frequency; A1 stands for the major allele; and A2 stands for the minor allele; effects are additive (+) or multiplicative (×) depending on whether the phenotype was log transformed. “R²” represents the percentage of phenotypic variance explained by the SNP. All SNP positions are in relation to build 35 of the human genome.

^aAssociations with p < 5 × 10⁻⁷.