Table 1.
Glycemic and hemodynamic measurements performed in diabetic animals and diabetic animals treated with ALT-711 for 1 or 3 weeks
| Nondiabetic controls | 9 weeks diabetes | Diabetes + ALT-711 for:
|
||
|---|---|---|---|---|
| 1 week | 3 weeks | |||
| Blood glucose (mmol/liter) | 6.0 ± 2.0 | 24.5 ± 3.2* | 23.3 ± 2.9 | 24.0 ± 3.5 |
| HbA1c (%) | 1.3 ± 0.3 | 4.7 ± 0.4* | 4.6 ± 0.5 | 4.6 ± 0.5 |
| Body weight (g) | 354 ± 29 | 258 ± 14* | 255 ± 16 | 251 ± 15 |
| Systolic BP (mm Hg) | 126 ± 11 | 111 ± 12* | 108 ± 11 | 109 ± 13 |
| Diastolic BP (mm Hg) | 98 ± 8 | 87 ± 15 | 83 ± 10 | 85 ± 16 |
| Mean BP (mm Hg) | 111 ± 10 | 98 ± 15 | 95 ± 10 | 96 ± 16 |
| Heart rate (beats/min) | 412 ± 66 | 321 ± 32* | 296 ± 25 | 320 ± 34 |
| Cardiac output (ml/min) | 69 ± 6 | 59 ± 15 | 62 ± 10 | 75 ± 18† |
| Cardiac index (ml/min per cm2) | 0.19 ± 0.02 | 0.19 ± 0.05 | 0.21 ± 0.03 | 0.25 ± 0.07† |
| TPR (103.dyne.sec/cm5) | 128 ± 17 | 141 ± 46 | 126 ± 31 | 107 ± 34‡ |
| TPR index (dyne.sec/cm3) | 359 ± 35 | 463 ± 170 | 429 ± 106 | 357 ± 123‡ |
| SAC (10−3 ml/mm Hg) | 6.9 ± 0.6 | 5.6 ± 1.8* | 6.4 ± 1.6 | 7.3 ± 3.3† |
| Zc (103.dyne.sec/m5) | 8.7 ± 3.1 | 13.3 ± 4.6* | 11.7 ± 4.2 | 8.6 ± 3.8† |
Values are mean ± SD. HbA1c, glycated hemoglobin; cardiac index, cardiac output corrected for body surface area; TPR index, TPR corrected for body surface area.
*
P < 0.05 vs. nondiabetic control animals.
†
P < 0.05;
‡
P = 0.075 by ANOVA vs. 9-week diabetic animals.