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. Author manuscript; available in PMC: 2009 Jan 15.
Published in final edited form as: Biochem Pharmacol. 2007 Jul 7;75(2):346–359. doi: 10.1016/j.bcp.2007.07.004

Figure 1.

Figure 1

Structure of MMPs. MMP consists of a prodomain, catalytic domain, hinge region, and hemopexin domain. In the catalytic domain, MMP has a Zn2+ binding site, and a binding site for the specific substrate. MMP has cysteine switch motif PRCGXPD in the prodomain. Matrilysins lack a hemopexin domain. MT-MMP has an additional transmembrane binding domain.