Fig. (3).

Erythropoietin (EPO) prevents DNA fragmentation during β-amyloid (Aβ) application in human neuroblastoma SH-SY5Y cells. Representative images illustrate DNA fragmentation with terminal deoxynucleotidyl transferase nick end labeling (TUNEL) in SH-SY5Y cells 24 hours after administration of Aβ (20 μM). Significant DNA fragmentation in SH-SY5Y cells is illustrated following Aβ treatment. In contrast, application of EPO (10 ng/ml) 1 hour prior to Aβ administration resulted in a significant reduction in DNA fragmentation when assessed 24 hours later.