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. Author manuscript; available in PMC: 2008 Feb 25.
Published in final edited form as: Nat Struct Mol Biol. 2007 Apr 22;14(5):406–412. doi: 10.1038/nsmb1232

Figure 4.

Figure 4

Identification of an autoinhibitory element in RABEX-5. (a) RABEX-5 truncation constructs. (b) Catalytic efficiency of RABEX-5 truncation constructs. Values are mean ± s.d. for n = 2. (c) Alignment of RABEX-5 sequences from diverse organisms (Hs, Homo sapiens; Xl, Xenopus laevis; Dr, Danio rerio; Dm, Drosophila melanogaster). Below the alignment is a hypothetical helical model for RABEX-5407–456 with conserved side chains depicted in blue (in the default rotamer conformation). The helix was constructed using PyMOL. (d) Effect of alanine substitutions on the catalytic efficiency of RABEX-5132–460. Values are mean ± s.d. for n = 2.