Fig. 2.

Averaged responses of 8 Vc units to thermal stimuli before and after chemical application.

A: Application of 10% EtOH followed 5 min later by 10% CA. Ethanol did not elicit a significant response (gray portion of PSTH). The CA response was significantly increased following EtOH (#, p<0.05). The cold response was significantly decreased at 1 min post-CA (+, p<0.001) as compared to pre-ethanol. There were no other significant changes in the thermal responses.

B: Application of 1% menthol followed 5 min later by 10% CA. The CA response post-menthol was significantly reduced compared to CA alone ($, p<0.001). The cold responses were similar to those following CA alone. The response at 1 min post-CA was significantly decreased (+, p<0.01) while the response at 5 min post-CA was significantly enhanced (*, p<0.05) as compared to the response pre-menthol. The heat responses were not significantly different.

C: Application of 10% CA followed 5 min later by 1% menthol. The menthol response post-CA was significantly reduced compared to menthol prior to CA ($, p<0.01; compare gray portions of PSTHs for menthol in A and B). Unlike following CA, the cold response was significantly enhanced at 1 min post-menthol (*, p<0.05), but not significantly different at 5 min post-menthol as compared to pre-CA. The heat responses did not change significantly.