Fig. 1.

Profiled in color are brain regions in which higher age (blue–green) and a sex-by-systolic blood pressure interaction (red–yellow) predicted a lower grey matter volume. The sex-by-blood pressure interaction was explained by men (n = 76), but not women (n = 53), showing a lower regional grey matter volume as a function of higher systolic blood pressure (see Fig. 3). Color-scaled t values (legends at lower right) were derived from a general linear model of voxel-wise grey matter volume that included total brain tissue volume as a nuisance variable. Montreal Neurological Institute coordinate values below each section of a grey matter template refer to the distance in millimeters relative to the midline for sagittal sections in this figure (+ = right; − = left) and to the anterior commissure for coronal sections in Fig. 2 (+ = anterior; − = posterior). In each section, white matter and cerebrospinal fluid are blackened.