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. Author manuscript; available in PMC: 2008 Jul 9.
Published in final edited form as: FEBS Lett. 2007 Nov 20;582(1):2–9. doi: 10.1016/j.febslet.2007.11.016

Figure 2.

Figure 2

Schematic diagram for a typical NR activation mechanism. Top: In the absence of ligand, NRs form a repressive complex with HDACs (histone deacetylases) via corepressor SMRT or NCOR (left). Ligand binding induces a dissociation of corepressors and a recruitment of coactivators including HAT (histone acetyl-transferase) and chromatin remodeling complexes (right). Bottom: some nuclear receptors are activated by ligand-independendent binding of the PGC-1 coactivator and subsequent recruitment of additional coactivator complexes.