Table 3.

Dose response findings from fixed-dose randomized trials of olanzapine reported in the literature

Disease state	Study design	Duration	Dose	N*	Dose response for efficacy outcome
					Yes
Chronic schizophrenia [16]	Double-blind, randomized	6 weeks	5, 10, or 15 mg/d	198	Positive linear trend
Chronic schizophrenia [17]	Double-blind, randomized	6 weeks	5, 10, or 15 mg/d	350	Positive linear trend
					No
Chronic schizophrenia or schizoaffective disorder [18]	Double-blind, randomized,	24 weeks	10, 15, or 20 mg/d	202	No significant trend
Schizophrenia or schizoaffective disorder [19]	Double-blind, randomized	8 weeks	10, 20, or 40 mg/d	599	No significant dose response