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. 2008 Jan 23;9:11. doi: 10.1186/1471-2199-9-11

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Copyright © 2008 Li et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Wnt3a stimulation of STF mediated by Fzd2 and Ror2 is inhibited by Lrp6 siRNA. A. H441 cells were transfected with pSV-β-gal (Promega, WI), STF, Fzd2 and Ror2WT with either Lrp6 siRNAs or negative control siRNAs, and then treated with conditioned media, L-CM or Wnt3aCM. Equal amounts of DNA, siRNAs and conditioned media were used in each assay. Luciferase values were normalized to beta-galactosidase for transfection efficiency. Data shown are the average ratios of normalized luciferase values in Wnt3aCM-treated cells over that of L-CM-treated cells. * indicates p < 0.05. B. Western blot analysis of levels of Lrp6, Lrp5 and alpha-tubulin in H441 cells transfected with either Lrp6 siRNA or negative control siRNA (Ctrl).