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. Author manuscript; available in PMC: 2009 Feb 1.
Published in final edited form as: Mol Cell. 2008 Feb 1;29(2):232–242. doi: 10.1016/j.molcel.2007.11.020

Figure 7.

Figure 7

Model of the chromosomal configuration of the Kit gene. In immature erythroid cells GATA-2 binds the -114 enhancer to form an activating chromatin loop. Upon maturation, GATA-1 replaces GATA-2 and increases the interaction among downstream elements at the expense of the enhancer/promoter interaction. Loss of the enhancer loop might contribute to repression of Kit. The effects of GATA-1 require FOG-1. The resolution limits of 3C preclude us from distinguishing whether the enhancer loops to the transcription start site or the +5 region. We favor the former possibility as enhancers commonly target promoter elements. The question mark represents possible intermediary protein complexes involved in loop formation.