Table 1. Susceptibility of small laboratory animals of various ages to fatal Thottapalayam virus meningoencephalitis*.
Host species | Age at injection, d | Illness onset, d | Mortality rate, % |
---|---|---|---|
Mus musculus | 1 | 7 | 100 |
5 | 7 | 100 | |
10 | 6 | 88 | |
14 | 6 | 94 | |
21 | 8 | 67 | |
Meriones unguiculatus | 1 | 9 | 100 |
5 | 11 | 100 | |
11 | 7 | 80 | |
16 | 14 | 100 | |
Peromyscus maniculatus | 4 | 11 | 100 |
Monodelphis domestica | 30 | – | 0 |
*Animals of various ages were injected intracerebrally with 6,000 PFU of Thottapalayam virus strain VRC-66412 and examined daily for neurologic signs and death.