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. 2007 Nov 9;111(5):2647–2656. doi: 10.1182/blood-2007-08-109710

Figure 1.

Figure 1

Decreased neovascularization of Matrigel implants in Rap1b−/− mice in the directed in vivo angiogenesis assay. Quantitation of calcein-AM fluorescent staining of cells recovered from angioreactors supplemented with 500 ng/mL VEGF (■) or 187.5 ng/mL bFGF and 62.5 ng/mL VEGF (▨) implanted in normal (WT) and Rap1b−/− (KO) mice. Shown are means; error bars are SEM (n = 3). Asterisks indicate the datasets that were compared in a t test for statistical significance. In both instances, there was a statistically significant decrease in neovascularization of Matrigel implants in Rap1b−/− mice (P < .05).