Table 2.
Characteristics of 200 adult patients with non-L3 ALL, by karyotype category
| Characteristic | Normal diploid, N = 31 | t(9;22)/BCR/ABL1, N = 36 | Other unfavorable, N = 19 | Miscellaneous, N = 54 | Nonevaluable, N = 60 | All patients, N = 200 |
|---|---|---|---|---|---|---|
| Sex, no. (%) | ||||||
| Female | 12 (39) | 19 (53) | 8 (42) | 17 (31) | 23 (38) | 79 (40) |
| Male | 19 (61) | 17 (47) | 11 (58) | 37 (69) | 37 (62) | 121 (61) |
| Race, no. (%) | ||||||
| Black | 2 (6) | 3 (8) | 2 (11) | 5 (9) | 2 (3) | 14 (7) |
| Hispanic | 10 (32) | 7 (19) | 1 (5) | 16 (30) | 16 (27) | 50 (25) |
| White, non-Hispanic | 18 (58) | 24 (67) | 14 (74) | 30 (56) | 36 (60) | 122 (61) |
| Other | 1 (3) | 2 (6) | 2 (11) | 3 (6) | 6 (10) | 14 (7) |
| Performance status, no. (%) | ||||||
| 0 to 1 | 29 (94) | 33 (92) | 18 (95) | 50 (93) | 52 (87) | 182 (91) |
| 2 to 3 | 2 (6) | 3 (8) | 1 (5) | 4 (7) | 8 (13) | 18 (9) |
| FAB classification (local diagnosis), no. (%) | ||||||
| L1 | 14 (45) | 9 (25) | 5 (26) | 20 (37) | 29 (48) | 77 (39) |
| L2 | 16 (52) | 24 (67) | 12 (63) | 29 (54) | 26 (43) | 107 (54) |
| Other, NOS | 1 (3) | 3 (8) | 2 (11) | 5 (9) | 5 (8) | 16 (8) |
| Median, age, y (range) | 25 (18-57) | 47 (17-64) | 31 (18-55) | 29 (17-63) | 38 (16-65) | 32 (16-65) |
| Median, WBCs, 1000/mm3, (range) | 11.5 (0.9-150.0) | 38.9 (1.4-141.3) | 22.5 (5.2-163.0) | 14.4 (0.6-396.6) | 5.2 (1.1-197.5) | 15.8 (0.6-396.6) |
| Peripheral blasts, % | 59 (0-91) | 64 (0-95) | 64 (20-97) | 49 (0-98) | 24 (0-92) | 52 (0-98) |
| Median peripheral blasts, 1000/mm3, (range) | 5.6 (0.0-136.5) | 29.3 (0.0-125.3) | 12.9 (1.6-124.9) | 7.5 (0.0-141.9) | 1.2 (0.0-173.8) | 8.1 (0.0-173.8) |
| Median hemoglobin, g/dL, (range) | 9.4 (4.7-18.2) | 9.9 (5.5-13.4) | 10.1 (7.0-14.1) | 9.4 (4.6-16.5) | 9.2 (4.2-18.2) | 9.7 (4.2-18.2) |
| Median platelets, 1000/mm3, (range) | 70 (16-675) | 36 (3-400) | 47 (10-171) | 48 (5-324) | 47 (3-371) | 48 (3-675) |
| Marrow blasts, % | 90 (32-99) | 88 (48-99) | 78 (38-95) | 89 (2-99) | 92 (17-99) | 90 (2-99) |
NOS indicates not otherwise specified; and WBC, white blood cells.