Table 2.
Genotype and allele frequencies of three FTO SNPs in cases/controls and discordant sisters. Significance for case-control and thin-obese sister allele frequency comparisons are given in the right column. Genotype comparisons are presented in Table 3.
| N | Genotypes | Alleles | Allele Freq. Difference | ||||
| rs1421085 | TT | TC | CC | T | C | ||
| Controls | 521 | .370 | .518 | .111 | .630 | .370 | |
| Cases | 523 | .256 | .474 | .270 | .493 | .507 | p = 3.5 × 10-10 |
| Thin Sisters | 92 | .337 | .554 | .109 | .614 | .386 | |
| Obese Sisters | 93 | .247 | .548 | .204 | .522 | .478 | p = 0.07 |
| rs17817449 | TT | TG | GG | T | G | ||
| Controls | 522 | .393 | .496 | .111 | .641 | .359 | |
| Cases | 527 | .275 | .469 | .256 | .509 | .491 | p = 1.2 × 10-9 |
| Thin Sisters | 98 | .347 | .571 | .082 | .633 | .367 | |
| Obese Sisters | 93 | .258 | .516 | .226 | .516 | .484 | p = 0.02 |
| rs9939609 | TT | TA | AA | T | A | ||
| Controls | 520 | .398 | .494 | .108 | .645 | .355 | |
| Cases | 527 | .288 | .459 | .252 | .518 | .482 | p = 3.7 × 10-9 |
| Thin Sisters | 98 | .367 | .541 | .092 | .638 | .362 | |
| Obese Sisters | 92 | .272 | .489 | .239 | .516 | .484 | p = 0.02 |