Figure 4.

Time courses of CREB phosphorylation activated by the D1-class dopamine receptor agonist, SKF-81297 (A), the cAMP stimulator, forskolin (B), and the L-type calcium channel agonist, BAY K 8644 (C). D1 agonist stimulation induces longer phosphorylation in striosomes than in the matrix of the caudoputamen, and the duration of CREB phosphorylation induced by SKF-81297 and forskolin is longer in the olfactory tubercle than in either compartment of the dorsal striatum. By contrast, in BAY K 8644-treated slice cultures, CREB phosphorylation is shorter in the olfactory tubercle than in the caudoputamen.