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. 1998 Apr 14;95(8):4708–4713. doi: 10.1073/pnas.95.8.4708

Figure 5.

Figure 5

Effects of agonist washout on the time courses of CREB phosphorylation activated by SKF-881297 (A) and by forskolin (B). Reducing concentrations of SKF-81297 and forskolin by replacing the agonist solutions with fresh medium (2 × 5 min) shifts the time-course curves of PCREB expression to the left for both the caudoputamen and the olfactory tubercle. Note that the differences in time course between the two regions are maintained.